Selected Publications

Genetic manipulation of an Ixodes scapularis cell line. Singh N, Rolandelli A, O’Neal AJ, Butler LR, Samaddar S, Laukaitis-Yousey HJ, Butnaru M, Mohr SE, Perrimon N, Pedra JHF. BioRxiv. 2023 September 8.556855; doi: https://doi.org/10.1101/2023.09.08.556855.

 

Tick hemocytes have pleiotropic roles in microbial infection and arthropod fitness. Rolandelli A, Laukaitis-Yousey HJ, Bogale HN, Singh N, Samaddar S, O’Neal AJ, Ferraz CR, Butnaru M, Mameli E, Xia B, Mendes MT, Butler LR, Marnin L, Cabrera Paz FE, Valencia LM, Rana VS, Skerry C, Pal U, Mohr SE, Perrimon N, Serre D, Pedra JHF. BioRxiv. 2023 August 31. 555785; doi: https://doi.org/10.1101/2023.08.31.555785.

 

Metabolic disruption impacts tick fitness and microbial relationships. Samaddar S, O'Neal AJ, Marnin L, Rolandelli A, Singh N, Wang X, Butler LR, Rangghran P, Laukaitis HJ, Cabrera Paz FE, Fiskum GM, Polster BM, Pedra JHF. BioRxiv. 2023 May 26.542501; doi: https://doi.org/10.1101/2023.05.26.542501.

 

Cholesterol contributes to risk, severity, and machine learning-driven diagnosis of Lyme disease. Forrest IS, O'Neal AJ, Pedra JHF, Do R. Clin Infect Dis. 2023 May 25;ciad307. doi: 10.1093/cid/ciad307.

 

Croquemort elicits activation of the immune deficiency pathway in ticks. O'Neal AJ, Singh N, Rolandelli A, Laukaitis HJ, Wang X, Shaw DK, Young BD, Narasimhan S, Dutta S, Snyder GA, Samaddar S, Marnin L, Butler LR, Mendes MT, Cabrera Paz FE, Valencia LM, Sundberg EJ, Fikrig E, Pal U, Weber DJ, Pedra JHF. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2208673120. doi: 10.1073/pnas.2208673120.

 

Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development. Rana VS, Kitsou C, Dutta S, Ronzetti MH, Zhang M, Bernard Q, Smith AA, Tomás-Cortázar J, Yang X, Wu MJ, Kepple O, Li W, Dwyer JE, Matias J, Baljinnyam B, Oliver JD, Rajeevan N, Pedra JHF, Narasimhan S, Wang Y, Munderloh U, Fikrig E, Simeonov A, Anguita J, Pal U. Science. 2023 Jan 13;379(6628):eabl3837. doi: 10.1126/science.abl3837.

 

Tick transmission of Borrelia burgdorferi to the murine host is not influenced by environmentally acquired midgut microbiota. Narasimhan S, Rajeevan N, Graham M, Wu MJ, DePonte K, Marion S, Masson O, O'Neal AJ, Pedra JHF, Sonenshine DE, Fikrig E. Microbiome. 2022 Oct 17;10(1):173. doi: 10.1186/s40168-022-01378-w.

 

Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection. Oliva Chávez AS, Wang X, Marnin L, Archer NK, Hammond HL, Carroll EEM, Shaw DK, Tully BG, Buskirk AD, Ford SL, Butler LR, Shahi P, Morozova K, Clement CC, Lawres L, Neal AJO, Mamoun CB, Mason KL, Hobbs BE, Scoles GA, Barry EM, Sonenshine DE, Pal U, Valenzuela JG, Sztein MB, Pasetti MF, Levin ML, Kotsyfakis M, Jay SM, Huntley JF, Miller LS, Santambrogio L, Pedra JHF. Nature Communications. 2021 Jun 17;12(1):3696. doi: 10.1038/s41467-021-23900-8. PMID: 34140472

 

Ticks resist skin commensals with immune factor of bacterial origin. Hayes BM, Radkov AD, Yarza F, Flores S, Kim J, Zhao Z, Lexa KW, Marnin L, Biboy J, Bowcut V, Vollmer W, Pedra JHF, Chou S. Cell. 2020 Dec 10;183(6):1562-1571.e12. doi: 10.1016/j.cell.2020.10.042. PMID: 33306955

 

Lipid hijacking: a unifying theme in vector-borne diseases. O'Neal AJ, Butler LR, Rolandelli A, Gilk SD, Pedra JHF. Elife. 2020 Oct 29;9:e61675. doi: 10.7554/eLife.61675. PMID:33118933

 

Immunometabolism in arthropod vectors: redefining interspecies relationships. Samaddar S, Marnin L, Butler LR, Pedra JHF. Trends Parasitol. 2020 Aug 18:S1471-4922(20)30193-8. doi: 10.1016/j.pt.2020.07.010. PMID:32819827

 

Interactions between Borrelia burgdorferi and ticks. Kurokawa C, Lynn GE, Pedra JHF, Pal U, Narasimhan S, Fikrig E. Nature Reviews Microbiology. 2020 Jul 10:1-14. doi: 10.1038/s41579-020-0400-5. PMID:32651470

 

Protective immunity and new vaccines for Lyme disease. Gomes-Solecki M, Arnaboldi PM, Backenson PB, Benach JL, Cooper CL, Dattwyler RJ, Diuk-Wasser M, Fikrig E, Hovius JW, Laegreid W, Lundberg U, Marconi RT, Marques AR, Molloy P, Narasimhan S, Pal U, Pedra JHF, Plotkin S, Rock DL, Rosa P, Telford SR, Tsao J, Yang XF, Schutzer SE. Clin Infect Dis. 2020 Apr 10;70(8):1768-1773. doi: 10.1093/cid/ciz872. PMID:31620776

 

p47 licenses activation of the immune deficiency pathway in the tick Ixodes scapularis. McClure Carroll EE, Wang X, Shaw DK, O'Neal AJ, Oliva Chávez AS, Brown LJ, Boradia VM, Hammond HL, Pedra JHF. Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):205-210. doi: 10.1073/pnas.1808905116. PMID:30559180

 

Vector immunity and evolutionary ecology: the harmonious dissonance. Shaw DK, Tate AT, Schneider DS, Levashina EA, Kagan JC, Pal U, Fikrig E, Pedra JHF. Trends Immunol. 2018 Nov;39(11):862-873. doi: 10.1016/j.it.2018.09.003. PMID:30301592.

 

Engineering of obligate intracellular bacteria: progress, challenges and paradigms. McClure EE, Chávez ASO, Shaw DK, Carlyon JA, Ganta RR, Noh SM, Wood DO, Bavoil PM, Brayton KA, Martinez JJ, McBride JW, Valdivia RH, Munderloh UG, Pedra JHF. Nature Reviews Microbiology, 2017 Jun 19. doi: 10.1038/nrmicro.2017.59. PMID:28626230.

 

Infection-derived lipids elicit an immune deficiency circuit in arthropods. Shaw DK, Wang X, Brown LJ, Chávez AS, Reif KE, Smith AA, Scott AJ, McClure EE, Boradia VM, Hammond HL, Sundberg EJ, Snyder GA, Liu L, DePonte K, Villar M, Ueti MW, de la Fuente J, Ernst RK, Pal U, Fikrig E, Pedra JH. Nature Communications 2017;8:14401. doi: 10.1038/ncomms14401. PMID:28195158.

 

The prostaglandin E2-EP3 receptor axis regulates Anaplasma phagocytophilum-mediated NLRC4 inflammasome activation. Wang X, Shaw DK, Hammond HL, Sutterwala FS, Rayamajhi M, Shirey KA, Perkins DJ, Bonventre JV, Velayutham TS, Evans SM, Rodino KG, VieBrock L, Scanlon KM, Carbonetti NH, Carlyon JA, Miao EA, McBride JW, Kotsyfakis M, Pedra JH. PLoS Pathog. 2016 Aug 2;12(8):e1005803.doi:10.1371/journal.ppat.1005803. PMID:27482714.

 

The tick protein sialostatin L2 binds to Annexin A2 and inhibits NLRC4-mediated inflammasome activation.Wang X, Shaw DK, Sakhon OS, Snyder GA, Sundberg EJ, Santambrogio L, Sutterwala FS, Dumler JS, Shirey KA, Perkins DJ, Richard K, Chagas AC, Calvo E, Kopecký J, Kotsyfakis M, Pedra JH. Infect Immun. 2016 May 24;84(6):1796-805. doi: 10.1128/IAI.01526-15. PMID:27045038

 

Genomic insights into the parasitic vector of Lyme disease, Ixodes scapularis.Ixodes scapularis International Consortium. Nature Communications, 2016 7:10507 doi: 10.1038/ncomms10507. PMID:26856261